Iciency What Is Severe Combined Immunodeficiency (SCID) and How Is It Treated?

Iciency Severe

Severe Combined Immunodeficiency (SCID)

Severe Combined Immunodeficiency (SCID) is a rare genetic disorder that affects the immune system. People with SCID are born without an immune system, meaning they are unable to fight off infections. Without treatment, babies with SCID may die from infections within the first months of life.

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The most common symptoms of SCID include frequent infections (such as a bronchitis, pneumonia, and ear infections), chronic diarrhea, failure to gain weight, rashes, and difficulty breathing.


SCID is diagnosed through blood tests and genetic testing. Blood tests can identify whether a person has a low level of infection-fighting white blood cells, which is a sign that they may have SCID. Genetic testing is used to identify the exact genetic mutation that is causing the disease.

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SCID can be treated with a bone marrow transplant from a healthy donor. The transplant is used to provide the patient with a new immune system. Other treatments may be needed to protect the patient from life-threatening infections until the new immune system is fully established.


There is no known way to prevent SCID, as it is caused by genetic mutations. However, there are diagnostic tests available that can identify the disorder in infants before they become ill. Early detection can improve the chances of successful treatment.

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